مشخصات پژوهش

خانه /Mentha mozaffarianii mediated ...
عنوان
Mentha mozaffarianii mediated biogenic zinc nanoparticles target selected cancer cell lines and microbial pathogens
نوع پژوهش مقاله چاپ‌شده
کلیدواژه‌ها
Antibacterial and antifungal activities Cancer Mentha mozaffarianii Nanoparticles
چکیده
Here we report the biosynthesis of zinc oxide nanoparticles (ZnO-NPs) using aqueous extract of medicinally active Mentha mozaffarianii for biomedical applications. ZnO-NPs were characterized by X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FE-SEM), Energy-dispersive X-ray (EDX) spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy. The sharp and narrow diffraction peaks in the whole spectrum revealed that the ZnO-NPs are nanosized and well crystalized. FE-SEM analysis exhibited the spherical shape of the biosynthesized ZnO-NPs (mean diameter of about 20–29 nm). EDX analysis confrmed the formation of highly pure ZnO-NPs. ZnO-NPs exerted distinct effects on cancer cell lines while posing no impact on normal fbroblast cells. ZnO-NPs were primarily effective against HeLa (IC50: 50.1 μg/ml) cells, followed by MDAMD231 (IC50: 54.9 μg/ml), and LS180 (63.4 μg/ml) cell lines. The biogenic ZnO-NPs revealed potent antimicrobial activity against two Gram-negative [Enterobacter aerogenes (maximum zone of inhibition (MZI): 20 mm) and Klebsiella pneumoniae (MZI: 22 mm)] and two Gram-positive [Bacillus subtilis (MZI: 23.2 mm) and Staphylococcus aureus] strains of bacteria, and four strains of fungi [C. glabrata (MZI: 17.5 mm), C. albicans (MZI: 21 mm), P. oryzae (MZI: 15 mm), C. neoformans (MZI: 16 mm)]. These fndings provide preliminary information for the development of anticancer and antimicrobial drugs using biosynthesized ZnO-NPs.
پژوهشگران مجتبی رنجبر (نفر اول)، محمود کیانی (نفر دوم)، فاطمه خاکدان (نفر سوم)