مشخصات پژوهش

To evaluatetheprotectiveeffectofliquoriceplantextract(LPE)onochratoxinA-induced nephrotoxicity,ratswereexposedtoochratoxinAfor28consecutivedays.Biochemicalanalyses showedthatochratoxinAelevatedtheserumlevelofcreatinine,bloodureanitrogen(BUN),alkaline phosphatase(ALP),alanineaminotransaminase(ALT),andmalondialdehyde(MDA)whileantioxidant power oftheserumwasdiminishedsignificantly(Po0.05). Histopathologicalexaminationsrevealed degenerativesymptomsinproximaltubules,congestionsinrenaltissue,andaremarkableinfiltration of theinflammatorycellsassignsofochratoxinAnephrotoxicity.Moreover,totalantioxidantpowerof the serumandMDAgenerationwasincreased.Thetestcompoundsmelatonin(MLT)andLPEalleviated mostofthebiochemicalalterations.Theresultsofthehistopathologicalinvestigationsofthekidneys supportedthesefindingsconfirmingtheprotectiveeffectsofthetestcompoundsalbeitwithsome differencesinantioxidantpotency.Takentogether,ourdatamaysuggestthatLPElikeMLTcould alleviateanochratoxinA-reducedantioxidantpowerofserumandlowerthetoxin-inducedMDA generation.HenceLPEmightbeconsideredasapracticallyantioxidantcompoundthatmaybe beneficialinthepreventionandtreatmentofochratoxicosis.