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Keywords
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spermatogenesis, spermatogonial stem cells, stem cell, transplantation,
fertility
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Abstract
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Spermatogenesis is initiated and sustained by a rare population of singular
spermatogonial stem cells (SSCs). These SSCs are connected to the basement membrane
of the seminiferous tubules and possess distinctive morphological characteristics. They
serve as a vital foundation for a robust stem cell system within the testis, crucial for
spermatogenesis and reproductive processes. The isolation and cultivation of human
SSCs would significantly enhance our understanding of germ and stem cell biology in
humans. Although a challenging endeavor, the recent advancements in enriching and
propagating spermatogonia carrying the male genome offer a significant stride toward
future transplantation and the restoration of fertility in clinical settings.
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