مشخصات پژوهش

Spermatogenesis is initiated and sustained by a rare population of singular spermatogonial stem cells (SSCs). These SSCs are connected to the basement membrane of the seminiferous tubules and possess distinctive morphological characteristics. They serve as a vital foundation for a robust stem cell system within the testis, crucial for spermatogenesis and reproductive processes. The isolation and cultivation of human SSCs would significantly enhance our understanding of germ and stem cell biology in humans. Although a challenging endeavor, the recent advancements in enriching and propagating spermatogonia carrying the male genome offer a significant stride toward future transplantation and the restoration of fertility in clinical settings.