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Keywords
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: Horse, Tendinopathy, Cell therapy, Stem
cell, Cell differentiation, Tissue engineering
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Abstract
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Tendon injuries, as one of the most common
orthopedic disorders, are the major cause of early
retirement or wastage among sport horses which
mainly affect the superficial digital flexor tendon
(SDFT). Tendon repair is a slow process, and tendon
tissue is often replaced by scar tissue. The current
treatment options are often followed by an
incomplete recovery that increases the susceptibility
to re-injury. Recently, cell therapy has been used in
veterinary medicine to treat tendon injuries, although
the risk of ectopic bone formation after cell injection
is possible in some cases. In vitro tenogenic induction
may overcome the mentioned risk in clinical
application. Moreover, a better understanding of
treatment strategies for musculoskeletal injuries in
horse may have future applications for human and
vice versa. This comprehensive review outlines the
current strategies of stem cell therapy in equine
tendon injury and in vitro tenogenic induction of
equine stem cell
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