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Title
Removal of amoxicillin from hospital waste using Fe2O3–Ag adsorbent and optimization by response surface methodology and machine learning prediction
Type Article
Keywords
Nanocomposite adsorbent; Pharmaceutical wastewater treatment; Antibiotic contamination; Machine learning optimization; Adsorption mechanism; Kinetic and isotherm studies
Abstract
Purpose Antibiotic pollution in hospital effluent is a significant environmental concern that contributes to the evolution of antibiotic-resistant bacteria. This study aims to provide effective removal strategies for antibiotics from wastewater. Materials and methods In this study, Fe2O3–Ag nanocomposites were prepared and characterized to enhance the sorption of Amoxicillin from water. We employed Response Surface Methodology (RSM) and machine learning models (XGBoost and Random Forest) to optimize the adsorption process, maximizing removal efficiency. The optimal conditions for Amoxicillin removal were determined to be a pH of 6.5, a contact time of 26 min, a temperature of 45 °C, and an adsorbent dosage of 0.185 g. Adsorption isotherm and kinetic studies indicated that the process followed the Langmuir model and pseudo-second-order kinetics, respectively. Results and Discussion Machine learning models demonstrated robust predictive performance, with an R2 value of 0.97 for XGBoost. These findings highlight the potential of Fe2O3–Ag nanocomposites as effective adsorbents for antibiotic removal, paving the way for sustainable wastewater treatment solutions. Conclusions In conclusion, Fe2O3–Ag nanocomposites can be recognized as effective adsorbents in the removal of antibiotics from wastewater, contributing to the improvement of sustainable wastewater management solutions.
Researchers Kimia Yavari (First researcher) , Changiz Karami (Second researcher) , Sara Bijari (Third researcher) , Diba Adami (Fourth researcher) , Mohammad Hassan Shahavi (Fifth researcher)