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Abstract
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The pharmacokinetic parameters of levamisole were determined in the Caspian
salmon after intramuscular (IM), oral by gavage, and oral by feed administrations.
Eighty-one healthy fish in three different groups received levamisole at the dose of
25 mg/fish by each route. Blood samples were collected at time points of 0, 0.5, 1, 2,
4, 6, 12, 14, and 24 hr after administrations. Plasma levamisole concentrations were
measured by a validated high-performance liquid chromatography (HPLC) assay and
were analyzed using a noncompartmental approach. The mean terminal half-life was
4.56, 3.95, and 2.91 hr for IM, gavage and feed routes, respectively. The peak plasma
concentration for IM, gavage, and feed routes of levamisole were 35.53, 4.63, and
8.36 μg/ml, respectively, at the time of 0.25 for IM, and 1 hr for gavage and feed. The
relative bioavailability for gavage and feed routes was 54.80 and 69.30. The similar
bioavailability for gavage and feed might be indicative of similar efficacy for these
routes of administrations. Further studies are warranted to evaluate
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