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چکیده
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The antibiotic resistance patterns against Staphylococcus aureus isolates of patients hospitalized in the intensive care unit Background:
Staphylococcus aureus is a Gram-positive pathogen and a common cause of various infections in community and hospital settings. Common clinical symptoms include fever, pneumonia, endocarditis, septic arthritis, and osteomyelitis [1]. Methicillin-resistant S. aureus (MRSA) is a multidrug-resistant (MDR) bacterium that can cause various infectious diseases and is related to increased mortality [2]. Treatment of MRSA infections remains challenging due to its ability to develop resistance to different classes of antibiotics [3]. In this study, the antimicrobial resistance pattern was performed among S.aureus isolates collected from patients administered in the ICU.
Methods:
In a cross-sectional study, 290 respiratory specimens were collected from ICU-admitted patients of two teaching hospitals of Tehran University of Medical Sciences. The S.aureus isolates were identified using biochemical tests and confirmed by PCR amplifying nuc-A and mec -A genes. The Kirby–Bauer disk diffusion and minimal inhibition concentration (MIC) methods were used to perform the antimicrobial susceptibility test against S. aureus isolates [4]. The proportion of methicillin-resistant S. aureus isolates was also documented.
Results:
S.aureus isolates were confirmed in 43 (14%) of 290 respiratory specimens. A high resistance rate of 74.4%, 62.8%, and 55.8% to azithromycin, ofloxacin, and ciprofloxacin was observed, respectively. The proportion of MRSA isolates was 48.8% (21 out of 43). Approximately 76.2% of MRSA isolates and 31.8% of MSSA isolates were resistant to at least five different antibiotics. Also, 53.3% of expired patients were infected with MRSA (non-significant). Conclusion: The emergence of MDR MRSA strains, which may be accompanied by increased mortality, is a growing concern. As a result, implementing antimicrobial therapy following antibiotic re
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