مشخصات پژوهش

Background Epithelial ovarian cancer (EOC), originating from the ovarian epithelial cells, represents approximately 90% of all ovarian cancer cases and includes several subtypes. Aim This study investigates the role of hub ribonucleoprotein genes in EOC progression. Methods Microarray datasets GSE28799 and GSE54388 from GEO were analyzed using Transcriptome Analysis Console (TAC) software for differential expression (p ≤ 0.05, LogFC ≥4). Upregulated RNP genes, including FBL and HNRNPC, were identified. Protein–protein interactions were analyzed using STRING and visualized in Cytoscape. Clustering was performed with Gephi software. Gene expression and alterations were validated using the HPA and cBioPortal databases. Results FBL and HNRNPC were significantly upregulated in EOC, playing key roles in tumor progression.