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Abstract
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Salinomycin (SLM) is an ionophore antibiotic used extensively in the
poultry industry for the control and prevention of coccidiosis. The
toxicity of the ionophore is thought to be due to oxidative damage caused
by the production of free radicals. Curcumin is a major component of
turmeric, which has a wide range of antioxidant, anti-inflammatory and
anticancer activities. The aim of this study was to evaluate the effect of
nanocurcumin (NC) as a natural antioxidant on broiler chickens poisoned
with a toxic dose of SLM. In this study, 60 broilers were randomly
divided into 5 groups. The first group was considered as control. The
second group received SLM at a dose of 300 mg/kg bw per day for 14
days. Groups 3, 4 and 5 received oral doses of NC at 50, 100 and 200
mg/kg bw per day for 14 days in addition to SLM. After 14 days, blood
and kidney tissue samples were collected for biochemical and
histopathological evaluation. It was observed that NC reduced the
incidence and severity of renal histopathological lesions. The highest
levels of inflammatory cells were observed in the cortex and medulla of
the SLM group and it appeared that treatment with NC improved the
condition and reduced the presence of inflammatory cells. It also
significantly improved renal histomorphometric parameters (P<0.05). It
seemed that SLM-induced adverse conditions can be reversed by oral
administration of NC.
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