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Abstract
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Hesperidin (HD) as a flavanone glycoside has pharmacological activities such as anti-inflammatory, antioxidant, and anti-cancer properties. However, poor solubility and bioavailability of hesperidin restrict its therapeutic effects. In this work, chitosan-functionalized Fe 3 O 4 magnetic nanoparticles (Cs-f-Fe 3 O 4 MNPs) were prepared to carry hesperidin. Hesperidin was isolated and purified from orange peel and then it was efficiently loaded into the synthesized magnetic nanoparticles (HD-Cs-f-Fe 3 O 4 MNPs). The antioxidant activity of synthesized MNPs was determined by 2, 2′-diphenyl-1-picrylhydrazyl (DPPH) free radical method. HD-Cs-f-Fe 3 O 4 MNPs have exhibited high DPPH scavenging activity and their antioxidant effect increased as the concentrations increased. The cytotoxicity of prepared MNPs were studied by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) assay. HD-Cs-f …
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