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Keywords
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MMP-2, signaling pathways, protein-protein interaction, differentiation, neurogenesis
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Abstract
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Background: Matrix Metalloproteinase-2 (MMP-2) is a zinc-containing enzyme with an extensive feature involving components of the extracellular matrix, cell surface, various bioactive molecules, and signaling pathways. MMP2 is investigating essential roles in various signaling pathways and progress in neural stem cells. Materials and Methods: According to the neurogenesis and neural stem cell differentiation network, this paper proposes a protein-protein interaction (PPI) extraction method. Our model does rely on bioinformatics tools. Results: We use the PPI extraction models heavily to rely heavily on parsing results from natural language processing tools like R language. We evaluated our model based on seven PPI extraction Cdkn1a, Stat3, Ctsb, Lcn2, Ccl2, Fgf2, and mTOR in neural stem cells differentiation and Sparc, shh, Gsk3b, Sdc1, Angpt2, Angpt1 is high co-function in neurogenesis by MMP-2. Conclusions: These studies show an essential role of MMP2 in neurogenesis and neural stem cells differentiation and confirm its importance in NPC activities crucial to brain development, growth, and recovery from injury.
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