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Keywords
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Sertoli cell, reproduction, spermatogenesis, male fertility, bioinformatics
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Abstract
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Spermatogenesis constitutes a complex and intricate cascade of differentiation, indispensable for the male
reproductive competence. The intercellular communication conduits of Sertoli cells (SCs) are pivotal in
orchestrating this cascade ensuring sustenance and development of germ cells. Single cells and bioinformatics
recently demonstrated articles are used for the regulatory modalities through which SCs modulate spermatogenesis,
specifically via androgen receptors (ARs), the transforming growth factor-beta/Smad axis, mitogenactivated
protein kinases, cAMP/protein kinase A (PKA), phosphatidylinositol 4,5-bisphosphate 3-kinase
(PI3k)/AKT serine threonine kinase (Akt), AMP-activated protein kinase, and AR pathways. Within this
framework, homeostasis of gap junction dynamics, cryptic sites and the activities at tight junctions and adherens
junctions, with the integrity of the testicular barrier, glucose assimilation, lactate distribution, being governed
also along with SC maturation. Disruptions in activities or abnormal concentration in derangements in
AR, cAMP/PKA, and PI3k/Akt pathways, and as well as the molecules that comprise them, would present
male infertility.
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