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Keywords
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gene expression, germ cell, male fertility, noncoding RNARNA, reproductive
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Abstract
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Noncoding RNAs (ncRNAs) are active regulators of a wide range of biological and
physiological processes, including the majority of mammalian reproductive events.
Knowledge of the biological activities of ncRNAs in the context of mammalian
reproduction will allow for a more comprehensive and comparative understanding of
male sterility and fertility. In this review, we describe recent advances in ncRNAmediated
control of mammalian reproduction and emphasize the importance of
ncRNAs in several aspects of mammalian reproduction, such as germ cell biogenesis
and reproductive organ activity. Furthermore, we focus on gene expression regulatory
feedback loops including hormones and ncRNA expression to better understand germ
cell commitment and reproductive organ function. Finally, this study shows the role of
ncRNAs in male reproductive failure and provides suggestions for further research.
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