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Keywords
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Composite film, Bacterial cellulose, Barhang gum, Essential oil, Antimicrobial, Wound dressing
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Abstract
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The gram-negative bacterium of Gluconacetobacter xylinum is widely used to produce high-quality cellulose in the
form of complex strips in microfiber bundles on a commercial scale. In this study, the film-forming potential of
bacterial cellulose in combination with polyvinyl alcohol (PVA, 5 % w/v) and Barhang seed gum (BSG, 0.5 % w/
v) loaded with summer savory (Satureja hortensis L.) essential oil (SSEO) to prepare a new wound dressing was
investigated. The X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FTIR), field emissionscanning
electron microscopy (FE-SEM), and thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller
(BET) surface area, in-vitro antibacterial, and in-vivo wound healing activities were performed to assess the
structure, morphology, stability, and bioactivity of biocomposite films. Results showed that the SSEO incorporation
into the polymeric matrix yielded smooth and transparent composite film with excellent thermal resistance.
A significantly robust antibacterial activity against gram-negative bacteria by the bio-film was found. The
healing process on mice models revealed that the SSEO-loaded composite film had a promising potential for
wound healing associated with improved collagen deposition and reduced inflammatory response.
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