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Abstract
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The Vimentin intermediate filament (VIF) is an essential cytoskeleton component. It shows dynamically
changing expression patterns throughout various phases of the differentiation process, suggesting
that the protein is physiologically important. Vimentin’s essential functions have recently been clear,
so Vimentin-deficient of animals was described as a change of morphology and signaling pathway.
Recent research has discovered many vital roles for Vimentin that were previously unknown. VIF
emerges as an organizer of many essential proteins involved in movement and cell signaling. The
highly dynamic and complicated phosphorylation of VIF seems to be a regulator mechanism for various
activities. Changes in IF expression patterns are often linked with cancer progression, especially
those leading to enhanced invasion and cellular migration. This review will discuss the function of
Vimentin intermediate filaments in normal cell physiology, cell adhesion structures, cell shape, and signaling
pathways. The genes interaction and gene network linked with Vimentin will be discussed in
more studies. However, research aimed at understanding the function of Vimentin in different signaling
cascades and gene interactions might offer novel methods for creating therapeutic medicines.
Enrichr GEO datasets used gene ontology (GO) and pathway enrichment analyses. STRING online was
used to predict the functional connections of proteins-proteins, followed by Cytoscape analysis to find
the master genes. Cytoscape and STRING research revealed that eight genes, Fas, Casp8, Casp6, Fadd,
Ripk1, Des, Tnnc2, and Tnnt3, were required for protein-protein interactions with Vimentin genes
involved in cell differentiation.
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